Alasdair Coles, at the end of the Q&A of his talk on brains and religious experience, points out that temporal lobe is the source of numinous awareness, closely associated with erotic experience, which in some is reported as the calm, peaceful awareness that God is with them (he specifies that PET studies show that this is mediated through the 5HT system). He adds that drugs affecting the same area can make an event that seems boring to one person seem to another to be full of deep significance for their life, for the world, for the universe.
So religious experience and the sense of how everything fits together are related, even physiologically.
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